{"title":"Epigenetics \u0026 Longevity Books","description":"\u003cp\u003eThe science behind your skin, your health, and your aging is written in your epigenome — and understanding it changes everything. 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It entails genetic control by factors other than a person's DNA sequence. Epigenetic modifications can activate or deactivate genes and determine which proteins are transcribed. The modifications have various effects on gene expression. The types of epigenetic changes include non-coding RNA, DNA methylation and histone modification. Epigenetic patterns may be affected by a number of lifestyle factors including tobacco smoking, food, exposure to environmental toxins, working on night shifts, obesity, alcohol consumption, psychological stress and physical activity. Epigenetics is a developing area of scientific study that demonstrates how environmental influences such as children's experiences affect the expression of their genes. This book unravels the recent studies in the field of epigenetics. It presents researches and studies performed by experts across the globe. 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After postdoctoral stays at the University of Edinburgh and Stanford University, he continued his career at the Center for Molecular Biology of the University of Heidelberg (ZMBH) in Germany. In 2000 became Professor at the Faculty of Medicine and Faculty of Biosciences of the University of Heidelberg and acting director of the ZMBH. In 2006 he was appointed founding chair of the new Department of Biosystems Science and Engineering (D-BSSE) of the ETH Zurich in Basel and Professor of Biosystems at the University of Basel. The major research areas of his laboratory focused on mechanisms of epigenetic gene control and cellular signaling. He is now Emeritus Professor.\u003c\/p\u003e Ueli Grossniklaus is Professor of Plant Developmental Genetics and Director of the Department of Plant and Microbial Biology of the University of Zurich. Grossniklaus earned his PhD working on \u003ci\u003eDrosophila\u003c\/i\u003e development under the mentorship of Walter J. 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Baird Phd\u003c\/b\u003e (Author)\u003c\/p\u003e\u003cp\u003e'Our Obesity Genes 'explains the genetic facts of why typical diets don't work and uniquely provides epigenetic modifiers to change the expression of our obesity genes. The epigenetic modifiers consist of known mental exercises used in many of our largest medical organizations, and customized for healthy weight loss. These mental acts are specially modified to be done anywhere in less than 15 minutes\/day Since what we prefer to eat is a habit, this program is designed to help you develop the eating habits of the world's healthiest and longest lived peoples. James D Baird PhD, the author, is a graduate engineer and a PhD in Natural Health, who has researched genetics and epigenetics for 20 years. 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It highlights the impact of the functional roles of CYP2D6 on clinical practice and drug development and also discusses implications for precise medicine, strategies to avoid adverse drug reactions, and paths for future research.\u003c\/p\u003e\u003cb\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/b\u003e\u003cp\u003eCytochrome P450 2D6 is a unique, valuable book focusing on a single but immensely powerful human gene. It provides the first single source of comprehensive information on CYP2D6 that serves as an important reference for medical, biomedical, pharmaceutical, and nursing researchers, practitioners, and students.\u003c\/p\u003e\u003ch3\u003eAuthor Biography\u003c\/h3\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eShufeng Zhou\u003c\/strong\u003e is the associate vice president of Global Medical Development and associate dean of international research in the College of Pharmacy of the University of South Florida in Tampa. 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Focusing on the existential dangers posed by neo-liberal and finance capitalist systems, the book brings to life the resources for resistance found within science studies and critical approaches to race, secularity, and disability. Throughout the book, Kierkegaard becomes an ally with ecological and developmental evolutionary theorists, as well as with science studies, critical race, and crip theorists who foreground the relational and impassioned nature of existence. \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003ch3\u003eAuthor Biography\u003c\/h3\u003e\u003cp\u003eAda S. Jaarsma is associate professor of philosophy at Mount Royal University. 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In this volume, sixteen leading evolutionary biologists and philosophers of science survey the conceptual changes that have emerged since Huxley's landmark publication, not only in such traditional domains of evolutionary biology as quantitative genetics and paleontology but also in such new fields of research as genomics and EvoDevo.\u003c\/p\u003e\u003cp\u003eMost of the contributors to \u003ci\u003eEvolution, the Extended Synthesis\u003c\/i\u003e accept many of the tenets of the classical framework but want to relax some of its assumptions and introduce significant conceptual augmentations of the basic Modern Synthesis structure--just as the architects of the Modern Synthesis themselves expanded and modulated previous versions of Darwinism. 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Sumner\u003c\/b\u003e (Author)\u003c\/p\u003e\u003cp\u003eThis unique text takes a holistic approach to show you how different biological and medical aspects of health operate at the cellular level all the way up to the societal level, and back again.\u003cbr\u003e \u003cbr\u003e It explains key biological aspects of health at the cellular level (such as epigenetics and oxidative stress) to give you a solid understanding of how health is created in the context of the person, before working upwards to examine public health issues ranging from cardiovascular disease to unemployment and loneliness. Throughout the text, you will encounter a diverse range of cross-cultural examples, real-world scenarios and key questions which will help you put the theories and cell-to-society perspective you have learned into practice. \u003cbr\u003e \u003cbr\u003e With interdisciplinary perspectives from psychoneuroimmunology and epidemiology, this book offers an integrated consideration of health and its biopsychosocial determinants. It is a must-read for students of health psychology, applied psychology, nursing, and public health, and it has been added to reading lists internationally.\u003cbr\u003e \u003cbr\u003e \u003cstrong\u003eRachel C. Sumner\u003c\/strong\u003e is a psychobiologist and chartered psychologist with the British Psychological Society Division of Health Psychology and a senior research fellow at Cardiff Metropolitan University. \u003cbr\u003e\u003c\/p\u003e\u003ch3\u003eAuthor Biography\u003c\/h3\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDr Rachel Sumner\u003c\/b\u003e is a psychobiologist and chartered psychologist with the British Psychological Society Division of Health Psychology. She is a senior research fellow in the Health and Human Performance Global Academy at Cardiff Metropolitan University. Rachel researches areas that consider how our lived environment impacts our health and wellbeing, using a variety of methods and outcomes to try and make sense of the very complicated ways that make our health a function of our lived experience. She is an interdisciplinary researcher who has made her career in collecting knowledge from various fields and trying to bring it together to make sense of the ways in which our health can be made better or worse through our lived experiences. She was previously the course director for the MSc Health Psychology at the University of Gloucestershire, from which this book has been adapted. This book was developed from a module that was written to give health psychology trainees a comprehensive understanding of health from its very smallest indices (our cells) right up to its largest measure (our societies). Taking both critical social and community aspects of health provides a comprehensive and inclusive means of accounting for the incredible intricacies of health at the individual and population level. 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By combining Scriptural truth with the latest in scientific research from fields such as neuroscience, epigenetics, and neurocardiology, Marci powerfully reveals answers that Christians need to know.\u003c\/p\u003e\u003cp\u003eTopics include: \u003c\/p\u003e\u003cp\u003e-Why so few are healed and how to change that.\u003c\/p\u003e\u003cp\u003e-Harnessing the power of the heart to flood every cell of your body with life.\u003c\/p\u003e\u003cp\u003e-DNA does not necessarily determine destiny.\u003c\/p\u003e\u003cp\u003e-Why the Bible and Epigenetics offer hope to parents of sick children.\u003c\/p\u003e\u003cp\u003e-How to end life-long depression, anxiety disorders, and OCD.\u003c\/p\u003e\u003cp\u003e-A possible connection between autoimmune disease and the heart.\u003c\/p\u003e\u003cp\u003e-How to biblically interpret ever-changing perspectives on nutrition.\u003c\/p\u003e\u003cp\u003eSick or well, everyone needs to know the life-giving truths found in God's Word. 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Landrigan\u003c\/b\u003e (Editor)\u003c\/p\u003e\u003cp\u003eChildren are exquisitely sensitive to hazards in the environment. Even minute quantities of toxic chemicals can trigger cellular changes that result in disease and disability that affect children across their lifespan. New discoveries in children's environmental health continue to elucidate the profound impacts of chemical, biological, physical and societal hazards on children's health and guide effective intervention. \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cem\u003eTextbook of Children's Environmental Health\u003c\/em\u003e is the landmark textbook channeling scientific findings into evidence-based strategies in children's environmental health. Edited by two internationally recognized pioneers in environmental pediatrics, this second edition presents up-to-date information on the chemical, biological, physical, and societal hazards that confront children in today's world. 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Arteriogenesis, sometimes also called therapeutic angiogenesis, refers to the body's own capacity to create a natural bypass around a narrowing or occluded arterial vessel. This book gives an insight into current knowledge and advances in vascular sciences and future prospects of therapeutic options. The utility and relevance of circulating biomarkers together with the potential of machine learning methods are discussed as well as the challenges and prospects of novel therapies such as protein- gene-, and stem cell therapy along with multicistronic multigene vectors and the use of microRNAs, exosomes, and secretomes. Vascular smooth muscle phenotype switch as a target to promote arteriogenesis is critically addressed, highlighting the problem of promoting atherosclerosis in parallel. Two articles even deal with cold-inducible RNA-binding protein CIRP\/CIRPB presenting it as promising target to promote vascularization concomitant the reduction in ischemic tissue damage. BMPR kinase inhibition is introduced to improve tissue repair in a hereditary form of vascular disorder, and the role of the AP-1 transcription factor JunB in blood vessel formation is described. Some more experimental oriented articles deal with the relevance of choosing the appropriate mouse strain for investigations as well as in vitro Matrigel plug assay as a potent method to investigate angiogenesis. Last but not least, two-photon intravital microscopy is presented as suitable tool to assess plaque angiogenesis in atherosclerotic lesions.\u003c\/p\u003e\u003cdiv\u003e\n\u003cstrong\u003eNumber of Pages:\u003c\/strong\u003e 230\u003c\/div\u003e\u003cdiv\u003e\n\u003cstrong\u003eDimensions:\u003c\/strong\u003e 0.75 x 9.61 x 6.69 IN\u003c\/div\u003e\u003cdiv\u003e\n\u003cstrong\u003ePublication Date:\u003c\/strong\u003e January 13, 2022\u003c\/div\u003e","brand":"Books by splitShops","offers":[{"title":"Default Title","offer_id":56905001664672,"sku":"9783036527161","price":73.62,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1036\/9515\/5360\/files\/09fa94d92ad26fe95854814656adf890.webp?v=1775579743"},{"product_id":"nanotherapy-for-brain-tumor-drug-delivery-paperback","title":"Nanotherapy for Brain Tumor Drug Delivery - Paperback","description":"\u003cp\u003eby \u003cb\u003eVivek Agrahari\u003c\/b\u003e (Editor), \u003cb\u003eAnthony Kim\u003c\/b\u003e (Editor), \u003cb\u003eVibhuti Agrahari\u003c\/b\u003e (Editor)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eSeries Preface...\u003cbr\u003ePreface...\u003cbr\u003eTable of Contents...\u003cbr\u003eContributing Authors... \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e1. Glioblastoma: State of Art of Treatments and Application of Polymeric and Lipidic Nanomedicines\u003cbr\u003eValeria Sgarbi, Jason T. Duskey, Ilaria Ottonelli, Natalia Oddone, Maria Angela Vandelli, Flavio Forni, Giovanni Tosi, and Barbara Ruozi \u003cp\u003e\u003c\/p\u003e2. Passive and Active Targeting of Brain Tumors\u003cbr\u003eAmr Hefnawy and Ibrahim M. El-Sherbiny \u003cp\u003e\u003c\/p\u003e3. Strategies to Modulate the Blood Brain Barrier for Directed Brain Tumor Targeting\u003cbr\u003ePaula Schiapparelli, Montserrat Lara-Velazquez, Rawan El-kharboosh, Hao Su, Honggang Cui, and Alfredo Quinones-Hinojosa \u003cp\u003e\u003c\/p\u003e4. Drug Delivery Approaches and Imaging Techniques for Brain Tumor\u003cbr\u003eMark Bell, Christine Pujol Rooks, and Vibhuti Agrahari \u003cp\u003e\u003c\/p\u003e5. Surface-Modified Nano-Drug Carriers for Brain Cancer Treatment\u003cbr\u003eAniket S. Wadajkar, Nina P. Connolly, Christine P. Carney, Pranjali P. Kanvinde, Jeffrey A. Winkles, Graeme F. Woodworth, and Anthony J. Kim \u003cp\u003e\u003c\/p\u003e6. Inorganic Nanostructures for Brain Tumor Management\u003cbr\u003eMohd Imran, Awais Ahmed Abrar Ahmed, Babak Kateb, and Ajeet Kaushik \u003cp\u003e\u003c\/p\u003e7. Strategies to Enhance the Distribution of Therapeutic Nanoparticles in the Brain by Convection Enhanced Delivery\u003cbr\u003eKarina Negron, Namir Khalasawi, and Jung Soo Suk \u003cp\u003e\u003c\/p\u003e8. Focused Ultrasound-Mediated Blood-Brain Barrier Disruption for Enhanced Drug Delivery to Brain Tumors\u003cbr\u003ePavlos Anastasiadis, Jeffrey A. Winkles, Anthony J. Kim, and Graeme F. Woodworth \u003cp\u003e\u003c\/p\u003e9. Neurosurgical Implant-Based Strategy for Brain Cancer Therapy\u003cbr\u003eJoshua Casaos, Noah Gorelick, and Betty Tyles \u003cp\u003e\u003c\/p\u003e10. Liposome-Templated Hydrogel Nanoparticles for Targeted Delivery of CRISPR\/Cas9 to Brain Tumors\u003cbr\u003eZeming Chen, Ann T. Chen, and Jiangbing Zhou \u003cp\u003e\u003c\/p\u003e11. Methods to Separate, Characterize, and Encapsulate Drug Molecules into Exosomes for Targeted Delivery and Treatment of Glioblastoma\u003cbr\u003eYen Nguyen, Sandeep Kaur, Hae Shim, Vaibhav Mundra, and Venkatareddy Nadithe \u003cp\u003e\u003c\/p\u003e12. Establishing Orthotopic Xenograft Glioblastoma Models for Use in Preclinical Development\u003cbr\u003eJoão Basso, José Sereno, Ana Fortuna, Miguel Castelo-Branco, and Carla Vitorino \u003cp\u003e\u003c\/p\u003eSubject Index List...\u003cp\u003e\u003c\/p\u003e\u003ch3\u003eBack Jacket\u003c\/h3\u003e\u003cp\u003eThis volume provides a guide on nanoformulations and other drug delivery approaches for both academic and industry scientists. The chapters in this book cover diverse topics and techniques in nanoparticle drug delivery, gene therapy, neurosurgical brain implant, exosomes, MRI-guided focused ultrasound (MRgFUS), and advanced preclinical glioblastoma multiforme animal models. Some chapters discuss state-of-the-art and innovative nanomedicines for glioblastoma, surface-modified nanoparticle drug carriers for brain cancer treatment, focused ultrasound (FUS)-mediated blood-brain barrier disruption for enhanced drug delivery to brain tumors; gene therapy delivery approaches to treat brain cancer, and a liposome-template hydrogel nanoparticles (LHNPs) as a powerful CRISPR\/Cas9 delivery vehicle. In the \u003ci\u003eNeuromethods\u003c\/i\u003e series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. \u003cbr\u003eCutting-edge and thorough, \u003ci\u003eNanotherapy for Brain Tumor Drug Delivery\u003c\/i\u003e is a valuable resource for the scientific community working on this important therapeutic field, and will help fast-track the clinical translation of revolutionary nanotechnologies for treating brain tumors. \u003cbr\u003e\u003c\/p\u003e\u003cdiv\u003e\n\u003cstrong\u003eNumber of Pages:\u003c\/strong\u003e 298\u003c\/div\u003e\u003cdiv\u003e\n\u003cstrong\u003eDimensions:\u003c\/strong\u003e 0.66 x 10 x 7 IN\u003c\/div\u003e\u003cdiv\u003e\n\u003cstrong\u003eIllustrated:\u003c\/strong\u003e Yes\u003c\/div\u003e\u003cdiv\u003e\n\u003cstrong\u003ePublication Date:\u003c\/strong\u003e December 02, 2021\u003c\/div\u003e","brand":"Books by splitShops","offers":[{"title":"Default Title","offer_id":56905001697440,"sku":"9781071610541","price":194.38,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1036\/9515\/5360\/files\/b08e9425a9cb64da53efe57e28375624.webp?v=1775579755"},{"product_id":"the-elusive-road-towards-effective-cancer-prevention-and-treatment-paperback","title":"The Elusive Road Towards Effective Cancer Prevention and Treatment - Paperback","description":"\u003cp\u003eby \u003cb\u003eFranklyn de Silva\u003c\/b\u003e (Author), \u003cb\u003eJane Alcorn\u003c\/b\u003e (Author)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eCancer will remain a global major health problem unless new diagnostic, prognostic, and management approaches are discovered to address both loss of life and quality of life. Here we summarize the general physiology, pathology, heterogeneity, and evolution of cancer, current status, limitations and challenges associated with prevention, incidence, treatment, survival, and mortality, as well as future directions with regards to solid tumors. Perspectives are provided on how to improve pre-clinical understandings, outcomes, and patient care. Further, this comprehensive, timely overview of the literature has educational value as part of an academic course, seminar, or as a supplementary text.\u003c\/p\u003e \u003cp\u003eFeatures: \u003c\/p\u003e \u003cul\u003e \u003cli\u003eThis book summarizes the current status, successes, difficulties, advancements, limitations, and challenges in medical interventions that impact patients' quality of life.\u003c\/li\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eIncludes concise descriptions of all relevant cell and molecular biology concepts including evolutionary paradigms, hallmarks of cancer, and heterogeneity to help understand the pathophysiology of cancer, cancer-associated disease conditions, and effective cancer therapy.\u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eContains an array of colorful figures and schematics summarizing complex informative pathological, physiological, and biochemical concepts.\u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eCovers a multitude of sub-topics pertaining to cancer biology including diagnosis; chemotherapy, radiotherapy and targeted therapy; metastasis; disseminated and circulating tumor cells, and cancer stem cells; drug resistance and cellular reprogramming; complex epigenetics; tumor-derived exosomes; oncogenic viruses; metabolic syndrome and cancer metabolism; convoluted neovascularization; efficient biomarkers; immunotherapy; role of nutraceuticals and natural products.\u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eProvides perspectives on how to improve pre-clinical understandings, and outcomes, linking toxicological, and pharmacological aspects in patient care.\u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eThis timely, relevant comprehensive assortment of scientific literature has educational value to a wider audience including as part of an academic course, seminar, or as a supplementary text.\u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e\n\u003c\/ul\u003e\u003ch3\u003eAuthor Biography\u003c\/h3\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eFranklyn De Silva - S. F. De Silva is a Ph.D. candidate in Pharmacy\/ Pharmaceutical Sciences (completion 2022) enrolled in the College of Graduate and Postdoctoral Studies, and the College of Pharmacy and Nutrition, at the University of Saskatchewan, Canada. He is a member of the Drug Discovery and Development Research Group. Franklyn has an AS in Biotechnology from Ellsworth College, Iowa, USA; a BS (double major: Biotechnology and Chemistry, minor in Biology) and MS (Biology: Cell Biology and Molecular Pharmacology) from West Texas A \u0026amp; M University, USA; and completed a biomedical research internship at Texas Tech University Health Sciences Center, USA. He has worked in the USA and Canada as a biomedical research scientist in areas involving cell \u0026amp; molecular biology, medicinal chemistry, pharmaco-kinetics\/dynamics, xenobiotics, nutrient transporters, cellular metabolism, small molecule drugs, natural products, and nutraceuticals.\u003c\/p\u003e\u003cp\u003eJane Alcorn - J. Alcorn is Dean and Professor of the College of Pharmacy and Nutrition, University of Saskatchewan. She has a Doctor of Veterinary Medicine from the Western College of Veterinary Medicine, University of Saskatchewan, and a Ph.D. in Pharmaceutical Sciences (Pharmacokinetics) from the University of Kentucky. Jane Alcorn is a member of the Drug Discovery and Development Research Group and the Cannabinoid Research Initiative of Saskatchewan. 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It covers essential topics related to regenerative medicine including basic science, needle technique, anatomy, and advanced applications of stem cells. The book is structured in a clear and concise manner, with each chapter building upon the previous one, offering a step-by-step practical manual for how to perform these procedures based on the latest regulatory changes through early 2023. \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003eThe book includes a comprehensive discussion of mesenchymal (or medicinal) stem cells and a history of stem cells, along with detailed chapters covering the shoulder, elbow, hand and wrist, hip, knee, and foot and ankle. Although this book is geared toward physicians and scientists, it also is an invaluable resource for students, patients, and all that are interested in regenerative medicine. This book is a departure from many medical textbooks as it is crafted with the reader in mind. It is written in a clear and easily comprehensible style that is both informative and engaging. With numerous helpful illustrations, it is a must-have for any medical library. \u003cp\u003e\u003c\/p\u003eOverall, \u003cb\u003eExosomes, PRP, and Stem Cells in Musculoskeletal Medicine\u003c\/b\u003e provides a complete guide to regenerative medicine, presenting the latest developments and practical guidelines in the field, and is an essential resource for anyone involved in the study or practice of regenerative medicine.\u003cdiv\u003e\n\u003cstrong\u003eNumber of Pages:\u003c\/strong\u003e 330\u003c\/div\u003e\u003cdiv\u003e\n\u003cstrong\u003eDimensions:\u003c\/strong\u003e 0.86 x 11 x 8.5 IN\u003c\/div\u003e\u003cdiv\u003e\n\u003cstrong\u003ePublication Date:\u003c\/strong\u003e April 29, 2023\u003c\/div\u003e","brand":"Books by splitShops","offers":[{"title":"Default Title","offer_id":56905001861280,"sku":"9798390973868","price":168.73,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1036\/9515\/5360\/files\/fa45ed11bfcdec5ac75e8647b3658e08.webp?v=1775579776"},{"product_id":"stem-cells-from-potential-to-promise-paperback","title":"Stem Cells: From Potential to Promise - Paperback","description":"\u003cp\u003eby \u003cb\u003eKhawaja Husnain Haider\u003c\/b\u003e (Editor)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eThe book highlights the therapeutic applications of various stem cells, and introduces readers to thymus stem cells and their applications in the reconstitution of thymic structure and function. It also discusses the significant role of mesenchymal stem cells (MSCs) in the treatment of autoimmune diseases and the use of MSC-derived exosomes in cell-free therapy. Moreover, it explores the application of hematopoietic stem cells in the vasculoprotection of the ischemially injured heart. 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